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KMID : 1161420140170101079
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Journal of Medicinal Food
2014 Volume.17 No. 10 p.1079 ~ p.1085
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Pharmacological Evidence of α2-Adrenergic Receptors in the Hypotensive Effect of Platonia insignis Mart.
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Mendes Marcelo Bezerra
da Silva-Filho Jose Couras
Sabino Carla Kelly Barroso
Arcanjo Daniel Dias Rufino
Sousa Cleyton Marcos Melo
Costa Isabella Cristhina Goncalves
Chaves Mariana Helena
Oliveira Rita de Cassia Meneses
Oliveira Aldeidia P.
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Abstract
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Platonia insignis Mart. (Clusiaceae) is a medicinal plant from the Brazilian Amazon region. The present study evaluated the biological potential of the ethanol extract (Pi-EtOH) and ethyl acetate fraction (Pi-EtOAc) of the P. insignis fruit shells on the cardiovascular system of rats. Pi-EtOH or Pi-EtOAc (12.5, 25, and 50?mg/kg) was administered intravenously in normotensive rats (260?300?g), and the mean arterial pressure and the heart rate were monitored. The Pi-EtOH induced hypotension (?11.56±0.89, ?7.43±0.85, and ?17.56±1.97 mmHg) followed by bradycardia in two highest doses (?8.89±3.62 and ?15.79±1.83 beats/min) and Pi-EtOAc, at the same doses, induced hypotension (?11.2±1.03, ?14.48±1.13, ?29.89±2.67 mmHg) more intensively, followed by tachycardia at the dose 12.5 and 25?mg/kg (15.64±2.06, 19.31±1.92 beats/min) and bradycardia at a dose of 50?mg/kg (?9.98±7.33 beats/min). The hypotensive response from Pi-EtOAc was not attenuated when used in the pretreatment with L-NAME, verapamil, propranolol, and hexamethonium. However, when using yohimbine, the hypotensive effect was inhibited (?4.42±1.28 (P<.05), ?3.29±0.99 (P<.05), 2.06±1.18 mmHg (P<.05); Student's t-test). Hence, the Pi-EtOAc seems to act similarly to the α2-adrenergic agonist in this hypotensive effect.
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KEYWORD
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blood pressure, cardiovascular, hypotension, Platonia insignis, yohimbine
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